10.1016/j.ajog.2020.03.021 [PMC free article] [PubMed] [CrossRef] [Google Scholar] 6. preterm management in the neonatal rigorous care unit (NICU) establishing during the COVID\19 pandemic. With this paper, we reported the case of a mother who presented medical symptoms of respiratory tract infection 10 days after the spontaneous delivery of a preterm newborn. The woman delivered a female neonate at 32 weeks? of gestational age, with birth weight appropriate for age. At birth, the newborn received noninvasive MC-Val-Cit-PAB-clindamycin ventilatory support (nCPAP) with FiO2?=?0.25. She was admitted to the Neonatology ward, where noninvasive ventilation was halted at 24?hours of age. Since birth, the newborn was fed with both breastfeeding and indicated maternal milk, and received Kangaroo Mother Care sessions. Eleven days apart from the delivery, the mother developed fever, anosmia, MC-Val-Cit-PAB-clindamycin and generalized malaise. Taking into account her provenience from a high\risk area, reverse transcription polymerase chain reaction (RT\PCR) assay for SARS\CoV\2 acid nucleic on mother nasopharyngeal swab was performed, resulting in positive (Division of Medicine and Surgery, Hygiene and General public Health Laboratory, University or college of Parma). In contrast, RT\PCR assay on breast milk, pumped at the symptoms’ onset, was unfavorable for SARS\CoV\2, allowing the prosecution of nutrition with expressed maternal milk. The neonate showed a good clinical course with normal vital parameters and grew up regularly. She was discharged with a weight gain of 910?g more than the birth excess weight. Timeline of length stay in hospital is usually reported in Physique?1. Open in a separate window Physique 1 Timeline of clinical length stay of the mother\baby dyade. +?=?positive swab; C?=?unfavorable swab During a stay in the hospital, mother and healthcare caregivers applied recommended hygiene measures, consisting of wearing surgical\mask, hand MC-Val-Cit-PAB-clindamycin washing, and using alcohol\based solutions to clean the surfaces. In this setting, no horizontal transmission occurred. Moreover, RT\PCR assay for SARS\CoV\2 performed on breast milk during mother febrile peak was unfavorable. This is in line with recent studies, RT\PCR assays on breast milk samples collected from affected women result unfavorable for SARS\CoV\2. 4 , 5 In our rigorous neonatal care unit the facility’s ability to accommodate mother\baby separation or colocation is usually lacking. Mother exceeded her quarantine at home. The decision regarding mother\baby separation was shared between the mother and the clinical team. Breastfeeding is usually important to the health and wellbeing of newborns and the protective impact of breastfeeding against infectious disease is usually of particular desire for the context of pandemics. The protective impact of breast milk against infectious lies in its components: immunoglobulins, lactoferrin, lysozyme, functional macrophages lymphocytes and monocytes, probiotic organisms and oligosaccharides. 6 Breast milk would provide IgA antibodies to structural computer virus protein which could play a role in suppressing the replication of computer virus. 7 Probiotic organisms and oligosaccharides support good colonization of the intestinal tract and suppress the growth of pathogenic bacteria. Growth factors in breastmilk also assist in the maturation of the infant’s own immune system. Favre et al 8 Rabbit Polyclonal to CAMK5 suggest that SARS\CoV\2 positive mothers must be isolated from newborns until viral shedding clears. However, any physical distance between mothers and infants impair the establishment of breastfeeding and bonding. The resourcing and other requirements associated with separating and isolating mothers’ and infants needs also to be considered. Salvatori et al 4 reported a case MC-Val-Cit-PAB-clindamycin series in which both the two mothers and two full\term babies were SARS\CoV\2 positive and stay in a rooming\in setting. Postnatal horizontal COVID\19 contamination occurred in newborns but expressed breast milk analysis did not reveal traces of the computer virus, so breastfeeding continued and the dyad was not separate. Lack of mother\to\baby transmission, when the mother was infected before.